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beta-2 Microglobulin Protein (AA 21-119) (His tag)

Name: beta-2 Microglobulin Protein (AA 21-119) (His tag)
Brand: antibodies-online
SKU: ABIN1880579
Availability: OutOfStock

B2M 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

产品编号 ABIN1880579

发货至: 中国

Datasheet as PDF

抗原 See all beta-2 Microglobulin (B2M) 蛋白

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

蛋白类型

Recombinant

产品特性

AA 21-119
宿主
12

6

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人
资源
48

11

10

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1
大肠杆菌（E. Coli）

标记

This beta-2 Microglobulin protein is labelled with His tag.

原理

Recombinant Human β-2-Microglobulin/B2M (N-6His)

序列

MGSSHHHHHH SSGLVPRGSH MIQRTPKIQV YSRHPAENGK SNFLNCYVSG FHPSDIEVDL LKNGERIEKV EHSDLSFSKD WSFYLLYYTE FTPTEKDEYA CRVNHVTLSQ PKIVKWDRDM

产品特性

Recombinant Human β-2-Microglobulin/B2M is produced with our E. coli expression system. The target protein is expressed with sequence (Ile21-Met119) of Human B2M fused with a 6His tag at the N-terminus.

纯度

> 95 % as determined by reducing SDS-PAGE.

过滤

0.2 μm filtered

内毒素水平

Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

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beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 1-119) protein (GST tag)
B2M 宿主: 人宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 1-119) protein (His tag)
B2M 宿主: 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (Active) protein (His tag)
B2M 宿主: 人宿主: HEK-293 Cells Recombinant > 97 % by SDS-PAGE. Active

限制

仅限研究用
状态

Lyophilized

溶解方式

It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

缓冲液

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

注意事项

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

储存条件

4 °C/-20 °C/-80 °C

储存方法

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
抗原

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

别名

B2M (B2M 产品)

别名

Ly-m11 Protein, beta2-m Protein, beta2m Protein, bwm Protein, wu:fa94c05 Protein, wu:fb10a09 Protein, b2m-W01 Protein, b2m-W03 Protein, b2m-Z01 Protein, b2m-Z02 Protein, b2m-Z03 Protein, B2M Protein, b2m Protein, B2MG Protein, wu:fb66f11 Protein, wu:fj01f08 Protein, zgc:64161 Protein, b-2-m Protein, beta-2-microglobulin Protein, beta-2 microglobulin Protein, beta-2-microglobulin S homeolog Protein, beta-2-microglobulin, like Protein, B2M Protein, B2m Protein, b2m Protein, b2m.S Protein, b2ml Protein

背景

β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

分子量

14 kDa

UniProt

P61769

途径

TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process