TPMT Protein (AA 4-244, partial) (GST tag)
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- 抗原 See all TPMT 蛋白
- TPMT (Thiopurine S-Methyltransferase (TPMT))
- 蛋白类型
- Recombinant
- 产品特性
- AA 4-244, partial
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This TPMT protein is labelled with GST tag.
- 应用范围
- ELISA
- 序列
- TRTSLDIEEY SDTEVQKNQV LTLEEWQDKW VNGKTAFHQE QGHQLLKKHL DTFLKGKSGL RVFFPLCGKA VEMKWFADRG HSVVGVEISE LGIQEFFTEQ NLSYSEEPIT EIPGTKVFKS SSGNISLYCC SIFDLPRTNI GKFDMIWDRG ALVAINPGDR KCYADTMFSL LGKKFQYLLC VLSYDPTKHP GPPFYVPHAE IERLFGKICN IRCLEKVDAF EERHKSWGID CLFEKLYLLT E
- 产品特性
- Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
- 纯度
- 95 %
- Top Product
- Discover our top product TPMT 蛋白
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Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (GST tag)
TPMT 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (Strep Tag)Crystallography grade TPMT 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Thiopurine S-Methyltransferase (TPMT) (AA 1-240) protein (Strep Tag)Crystallography grade TPMT 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Thiopurine S-Methyltransferase (TPMT) protein (Myc-DYKDDDDK Tag)TPMT 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 说明
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The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- 0.2-2 mg/mL
- 缓冲液
- Tris-based buffer, 50 % glycerol
- 注意事项
- Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
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- 抗原
- TPMT (Thiopurine S-Methyltransferase (TPMT))
- 别名
- Thiopurine S-methyltransferase protein (TPMT 产品)
- 别名
- MGC84277 Protein, AW106912 Protein, NHLRC1 Protein, thiopurine S-methyltransferase L homeolog Protein, thiopurine S-methyltransferase, tandem duplicate 2 Protein, thiopurine S-methyltransferase TpmT Protein, thiopurine S-methyltransferase Protein, Thiopurine S-methyltransferase Protein, thiopurine methyltransferase Protein, tpmt.L Protein, tpmt.2 Protein, tpmT Protein, MCA0794 Protein, Pnap_4948 Protein, Hhal_1383 Protein, TK90_1044 Protein, Slit_1144 Protein, Tint_0842 Protein, Fbal_3334 Protein, Celly_3188 Protein, Weevi_1737 Protein, Psefu_2696 Protein, Metme_3860 Protein, Tpmt Protein, TPMT Protein
- 背景
- Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
- 分子量
- 55.1 kD
- UniProt
- P51580
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