Ectodysplasin A Protein (EDA) (AA 240-391, Extracellular Domain, Soluble) (DYKDDDDK Tag)
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- 抗原 See all Ectodysplasin A (EDA) 蛋白
- Ectodysplasin A (EDA)
- 蛋白类型
- Recombinant
- 产品特性
- Soluble, Extracellular Domain, AA 240-391
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宿主
- 小鼠, 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Ectodysplasin A protein is labelled with DYKDDDDK Tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human and mouse EDAR (ectodysplasin-A1 receptor).
- 交叉反应
- 人, 小鼠
- 产品特性
- The extracellular domain of human EDA-A1 (aa 240-391) is fused at the N-terminus to a FLAG®-tag.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product EDA 蛋白
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Ectodysplasin A (EDA) (AA 245-391) protein (His-DYKDDDDK-Strep II Tag)
EDA 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Ectodysplasin A (EDA) (AA 245-391) protein (His tag)EDA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Ectodysplasin A (EDA) (AA 245-389) protein (His-DYKDDDDK-Strep II Tag)EDA 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Ectodysplasin A (EDA) (AA 1-391) protein (Strep Tag)Crystallography grade EDA 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Ectodysplasin A (EDA) (AA 1-391) protein (Strep Tag)Crystallography grade EDA 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Ectodysplasin A (EDA) (AA 63-391) protein (His tag)Crystallography grade EDA 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ectodysplasin A (EDA) (AA 63-391) protein (His tag)Crystallography grade EDA 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ectodysplasin A (EDA) (AA 160-391) protein (rho-1D4 tag)Crystallography grade EDA 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Ectodysplasin A (EDA) (AA 160-391) protein (rho-1D4 tag)Crystallography grade EDA 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 100 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- Ectodysplasin A (EDA)
- 别名
- EDA-A1 (EDA 产品)
- 别名
- ECTD1 Protein, ED1 Protein, ED1-A1 Protein, ED1-A2 Protein, EDA-A1 Protein, EDA-A2 Protein, EDA1 Protein, EDA2 Protein, HED Protein, HED1 Protein, ODT1 Protein, STHAGX1 Protein, XHED Protein, XLHED Protein, si:ch73-223d24.5 Protein, Ed1 Protein, Eda-A1 Protein, Eda-A2 Protein, Ta Protein, tabby Protein, RGD1563178 Protein, ectodysplasin A Protein, ectodysplasin-A Protein, EDA Protein, eda Protein, Eda Protein
- 背景
- The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.
- 分子量
- ~19kDa (SDS-PAGE)
- UniProt
- Q92838
- 途径
- Tube Formation
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