PRKAB2 Protein (His tag)
-
- 抗原 See all PRKAB2 蛋白
- PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- 大肠杆菌(E. Coli)
- 标记
- This PRKAB2 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 纯度
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product PRKAB2 蛋白
-
-
- 说明
-
Synonyms: 5'-AMP-activated protein kinase subunit beta-2
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1.0 mg/ml (determined by Bradford assay)
- 缓冲液
- 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 2 M Urea
- 储存条件
- 4 °C
- 储存方法
- Avoid repeated freezing and thawing cycles.
-
- 抗原
- PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))
- 别名
- PRKAB2 (PRKAB2 产品)
- 别名
- prkab2 Protein, MGC64365 Protein, PRKAB2 Protein, DKFZp469M1118 Protein, 5730553K21Rik Protein, AW049591 Protein, BB124140 Protein, protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog Protein, protein kinase AMP-activated non-catalytic subunit beta 2 Protein, protein kinase, AMP-activated, beta 2 non-catalytic subunit Protein, prkab2.L Protein, PRKAB2 Protein, prkab2 Protein, Prkab2 Protein
- 背景
- PRKAB2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. PRKAB2 may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Recombinant human PRKAB2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- 分子量
- 32.8 kDa(296aa)
- NCBI登录号
- NP_005390
- 途径
- AMPK Signaling, Warburg Effect
-