Pro BDNF Protein (AA 19-247)
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北京 101111
Quick Overview for Pro BDNF Protein (AA 19-247) (ABIN1097403)
抗原
蛋白类型
宿主
资源
纯度
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产品特性
- AA 19-247
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原理
- Recombinant Human Pro-Brain-Derived Neurotrophic Factor/pro-BDNF
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序列
- MAPMKEANIR GQGGLAYPGV RTHGTLESVN GPKAGSRGLT SLADTFEHVI EELLDEDQKV RPNEENNKDA DLYTSRVMLS SQVPLEPPLL FLLEEYKNYL DAANMSMRVR RHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
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产品特性
- Recombinant Human pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A,R127A,R128A) is expressed.
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过滤
- Sterile filtered
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内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Pro-Brain-Derived Neurotrophic Factor (proBDNF) protein
proBDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Pro-Brain-Derived Neurotrophic Factor (proBDNF) (Active) proteinproBDNF 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant ≥98 % (HPLC) WB, in vivo, in vitro Active
Pro-Brain-Derived Neurotrophic Factor (proBDNF) (Active) protein (Biotin)proBDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant WB, CC, LCI Active
Pro-Brain-Derived Neurotrophic Factor (proBDNF) (V66M) (Active) proteinproBDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant ≥98 % (HPLC) WB, CC Active
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
缓冲液
- Supplied as a filtered solution of PBS, pH 8.0.
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注意事项
- minimize freeze-thaw cycles,handle under sterile conditions after opening
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储存条件
- -80 °C
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储存方法
- Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
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背景
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Alternative Names: Brain-Derived Neurotrophic Factor, BDNF, AbrineurinThe precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
Alternative Names: Brain-Derived Neurotrophic Factor, BDNF, Abrineurin -
分子量
- 52 kDa
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UniProt
- P23560
抗原
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