Pro BDNF 蛋白
proBDNF
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 95 % as determined by reducing SDS-PAGE.
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- 抗原 See all Pro BDNF (proBDNF) products
- Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247 (R125A,R127A,R128A) is expressed.
- 产品特性
- Extracellular Domain Protein
- 纯度
- Greater than 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- a 0.2 μm filtered solution of PBS, pH 8.0.
- 储存条件
- -20 °C
- 储存方法
- Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Pro BDNF (proBDNF) (Pro-Brain-Derived Neurotrophic Factor (proBDNF))
- 别名
- pro-BDNF (proBDNF 产品)
- 背景
- Brain-Derived Neurotrophic Factor, BDNF, AbrineurinThe precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
- 分子量
- 25.6 KDa
- UniProt
- P23560
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