SLAMF6 Protein (AA 28-225) (His tag)
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- 抗原 See all SLAMF6 蛋白
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- 蛋白类型
- Recombinant
- 产品特性
- AA 28-225
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宿主
- 人
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资源
- 人细胞
- 标记
- This SLAMF6 protein is labelled with His tag.
- 原理
- Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)
- 序列
- LMVNGILGES VTLPLEFPAG EKVNFITWLF NETSLAFIVP HETKSPEIHV TNPKQGKRLN FTQSYSLQLS NLKMEDTGSY RAQISTKTSA KLSSYTLRIL RQLRNIQVTN HSQLFQNMTC ELHLTCSVED ADDNVSFRWE ALGNTLSSQP NLTVSWDPRI SSEQDYTCIA ENAVSNLSFS VSAQKLCEDV KIQYTDTKVD HHHHHH
- 产品特性
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Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His)
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product SLAMF6 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- 别名
- SLAM Family Member 6/SLAMF6 (SLAMF6 产品)
- 别名
- SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein
- 背景
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Recombinant Human SLAM Family Member 6/SLAMF6 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln22-Met226) of Human SLAMF6 fused with a polyhistidine tag at the C-terminus.
SLAM Family Member 6 (SLAMF6) is a 60 kDa single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 AA extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 AA transmembrane segment and an 84 AA cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity. - 分子量
- 23.98 kDa
- UniProt
- Q96DU3
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