PVRL1 Protein (AA 31-334) (His tag)
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- 抗原 See all PVRL1 蛋白
- PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 31-334
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宿主
- 人
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资源
- 人细胞
- 标记
- This PVRL1 protein is labelled with His tag.
- 原理
- Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)
- 序列
- QVVQVNDSMY GFIGTDVVLH CSFANPLPSV KITQVTWQKS TNGSKQNVAI YNPSMGVSVL APYRERVEFL RPSFTDGTIR LSRLELEDEG VYICEFATFP TGNRESQLNL TVMAKPTNWI EGTQAVLRAK KGQDDKVLVA TCTSANGKPP SVVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH QQSLACIVNY HMDRFKESLT LNVQYEPEVT IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL FFKGPINYSL AGTYICEATN PIGTRSGQVE VNITVDHHHH HH
- 产品特性
- Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Gln31-Thr334) of Human PVRL1 fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product PVRL1 蛋白
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Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 31-334) protein (His-Avi Tag)
PVRL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 31-334) protein (His-Avi Tag,Biotin)PVRL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 31-334) (Active) protein (Fc Tag)PVRL1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 1-352) protein (GST tag)PVRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 33-142) protein (GST tag)PVRL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) protein (His tag)PVRL1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) protein (Fc Tag)PVRL1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 377-517) protein (His tag)Crystallography grade PVRL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 376-515) protein (His tag)Crystallography grade PVRL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (AA 31-355) protein (His tag)Crystallography grade PVRL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - 有效期
- 3 months
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- 抗原
- PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))
- 别名
- nectin-1 (PVRL1 产品)
- 别名
- CD111 Protein, CLPED1 Protein, ED4 Protein, HIgR Protein, HVEC Protein, OFC7 Protein, PRR Protein, PRR1 Protein, PVRR Protein, PVRR1 Protein, SK-12 Protein, nectin-1 Protein, prr1 Protein, PVRL1 Protein, pvrl1 Protein, AI835281 Protein, AW549174 Protein, Cd111 Protein, HveC Protein, cd111 Protein, cd112 Protein, clped1 Protein, ed4 Protein, higr Protein, hveb Protein, hvec Protein, nectin-2 Protein, ofc7 Protein, prr Protein, prr2 Protein, pvrl2 Protein, pvrl2.L Protein, pvrr Protein, pvrr1 Protein, pvrr2 Protein, sk-12 Protein, nectin cell adhesion molecule 1 Protein, nectin-1 Protein, Poliovirus receptor-related protein 1 Protein, poliovirus receptor-related 1 (herpesvirus entry mediator C) Protein, nectin cell adhesion molecule 2 L homeolog Protein, NECTIN1 Protein, LOC100145553 Protein, pvrl1 Protein, nectin1 Protein, Nectin1 Protein, PVRL1 Protein, nectin2.L Protein
- Sub Type
- Fusionprotein
- 背景
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Nectin-1 is a type I transmembrane glycoprotein belonging to the Ig superfamily. Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Nectin ECDs contain three Ig like domains: an N terminal V type that mediates ligand binding, and two C2 type. Nectin-1 binds viral Glycoprotein D to mediate Herpesvirus (but not Poxvirus) entry into vaginal mucosa, sensory neurons and fibroblasts. In forming adherens junctions and synapses, Nectin-1 and Nectin-3 initiate cell-cell interactions, recruiting alphavbeta3 integrin extracellularly and cadherins intracellularly through afadin and other junctional proteins. These interactions organize the cytoskeleton, strengthen attachment to basement membrane and promote further cell-cell connections. Nectin-1 and Nectin-3 have been found to localize assymetrically along the chemical synapse, with Nectin-1 primarily on the axonal side and Nectin-3 on the dendritic side. Deficiency of Nectin-1 can result in cleft lip/palate ectodermal dysplasia. Nectin-1 downregulation in epithelial cancers is mediated in part by ectodomain shedding, but it may contribute to invasiveness.
Alternative Names: Poliovirus Receptor-Related Protein 1, Herpes Virus Entry Mediator C, Herpesvirus Entry Mediator C, HveC, Herpesvirus Ig-Like Receptor, HIgR, Nectin-1, CD111, PVRL1, HVEC, PRR1 - 分子量
- 34.99 kDa
- UniProt
- Q15223
- 途径
- Cell-Cell Junction Organization
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