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抗Mouse (Murine) NUP214 抗体:
抗Human NUP214 抗体:
Human Polyclonal NUP214 Primary Antibody for ELISA, WB - ABIN563519
Stochaj, Ba?ski, Kodiha, Matusiewicz: The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase. in Experimental cell research 2006
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Human Polyclonal NUP214 Primary Antibody for IP, WB - ABIN151667
Quentmeier, Schneider, Roehrs, Romani, Zaborski, Macleod, Drexler: SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines. in Journal of hematology & oncology 2009
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Human Polyclonal NUP214 Primary Antibody for ICC, IF - ABIN151666
Yu, Boyce, Wands, Bond, Bertozzi, Kohler: Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. in Proceedings of the National Academy of Sciences of the United States of America 2012
A major function of DNup88 is to anchor DNup214 and CRM1 (显示 XPO1 抗体) on the nuclear envelope and thereby attenuate NES (显示 NES 抗体)-mediated nuclear export.
The FG repeats of Nup153 (显示 NUP153 抗体) are necessary for its function in transport, whereas the remainder of the protein maintains pore integrity.
RNA-sequencing proved to be a valuable tool for the detection of a fusion of genes DEK (显示 DEK 抗体) and NUP214 in a leukemia that showed cryptic cytogenetic rearrangement of chromosome band 9q34.
SQSTM1 (显示 SQSTM1 抗体)-Nup214, although mostly cytoplasmic, also forms nuclear bodies and inhibits nuclear protein (显示 RDBP 抗体) but not poly(A)(+) RNA export.
We have identified NUP214, a member of the massive nuclear pore complex, as a novel miR (显示 MLXIP 抗体)-133b target.
t(6;9)/DEK (显示 DEK 抗体)-NUP214 represents a unique subtype of acute myeloid leukemia (显示 BCL11A 抗体) with a high risk of relapse.
Both in vitro hexon binding and in vivo nuclear import of the adenovirus genome were strongly reduced in Nup214-depleted cells suggesting that Nup214 is a major binding site of adenovirus during infection.
NUP214-ABL1 (显示 ABL1 抗体)-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK (显示 LCK 抗体) kinase and various interacting proteins.
the expression of the fusion gene DEK (显示 DEK 抗体)-NUP214 leads to increased cellular proliferation. We show that this is dependent on upregulation of the signal transduction protein mTOR (显示 FRAP1 抗体) with subsequent effects on protein synthesis and glucose metabolism.
When compared with SET-NUP214-negative patients, SET-NUP214-positive patients showed a significantly higher rate of corticosteroid resistance (91% vs 44%; P = .003) and chemotherapy resistance (100% vs 44%; P = .0001).
The expression of endogenous Nup214 is significantly down-regulated by the reverse inserted lentiviral promoter
Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1 (显示 XPO1 抗体).
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.
, nucleoporin 214
, nucleoporin 214kDa
, nuclear pore complex protein Nup214-like
, 214 kDa nucleoporin
, nuclear pore complex protein Nup214
, nucleoporin Nup214
, CAN protein, putative oncogene