Proprotein Convertase Subtilisin/kexin Type 9 蛋白
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| PCSK9 Protein (AA 35-694) (His tag) | 小鼠 | HEK-293 Cells |
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| PCSK9 Protein (AA 151-811) (His tag) | Cynomolgus | HEK-293 Cells |
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| PCSK9 Protein (AA 31-692) (His tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 31-692) (His tag,AVI tag,Biotin) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 31-692) (Fc Tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (His tag) | 小鼠 | HEK-293 Cells |
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| PCSK9 Protein (His tag) | 大鼠 | HEK-293 Cells |
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| PCSK9 Protein (AA 1-678) (GST tag) | 人 | 小麦胚 |
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| PCSK9 Protein (AA 35-155, AA 156-694) (His tag) | 小鼠 | HEK-293 Cells |
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| PCSK9 Protein (AA 31-692) (Fc Tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 31-227) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| PCSK9 Protein (AA 31-692) (His tag) | 人 | 人细胞 |
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| PCSK9 Protein (AA 35-692) (His tag) | 小鼠 | 人细胞 |
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| PCSK9 Protein (AA 31-152, AA 153-692) (His tag) | 猕猴 | 人细胞 |
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| PCSK9 Protein (His tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 35-694) (His tag) | 小鼠 | Mammalian Cells |
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| PCSK9 Protein (AA 31-692, D374Y) (His tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 1-692) (His tag) | 人 | HEK-293 Cells |
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| PCSK9 Protein (AA 1-691) (His tag) | 大鼠 | HEK-293 Cells |
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| PCSK9 Protein (AA 31-152, AA 153-692) (His tag) | Macaca nemestrina | HEK-293 Cells |
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Protein
- SDS (SDS-PAGE: 有验证图片)
- SPR (Surface Plasmon Resonance: 有验证图片)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: 有验证图片)
- SPR (Surface Plasmon Resonance: 有验证图片)
- 宿主
- Cynomolgus
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- Bind (Binding Studies: 有验证图片)
10 references - 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >97 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- Bind (Binding Studies: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >92 % as determined by reduced SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- AM (Affinity Measurement: 所列应用)
- ADA (Antibody Drug Assay: 所列应用)
- IA (Immunoassay: 所列应用)
- ScA (Screening Assay: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >90 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- 宿主
- 人
- 宿主
- 人细胞
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- 宿主
- 小鼠
- 宿主
- 人细胞
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- 宿主
- 猕猴
- 宿主
- 人细胞
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 92 % by SDS-PAGE.
- 生物活性
- Active
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 小鼠
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- 宿主
- Macaca nemestrina
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Latest Publications for our Proprotein Convertase Subtilisin/kexin Type 9 蛋白
: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." in: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).
: "PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Calcium-Mediated Allostery of the EGF Fold." in: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
: "PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Calcium-Mediated Allostery of the EGF Fold." in: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
Aliases for Proprotein Convertase Subtilisin/kexin Type 9 蛋白
proprotein convertase subtilisin/kexin type 9 (PCSK9) 蛋白proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) 蛋白
proprotein convertase subtilisin/kexin type 9 (pcsk9) 蛋白
proprotein convertase subtilisin/kexin type 9 (Pcsk9) 蛋白
AI415265 蛋白
AI747682 蛋白
FH3 蛋白
HCHOLA3 蛋白
LDLCQ1 蛋白
NARC-1 蛋白
NARC1 蛋白
Narc1 蛋白
PC9 蛋白
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