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Proprotein Convertase Subtilisin/kexin Type 9 蛋白

(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].

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  • 抗原: PCSK9
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN7313126
PCSK9 Protein (AA 31-692) PCSK9 · Protein 人 人细胞
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
  • 50 μg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7585446
PCSK9 Protein (AA 152-691) (His tag) PCSK9 · Protein 大鼠 酵母菌
  • ELISA (ELISA: 所列应用)
  • 100 μg
  • 1 mg
发货至: 中国
ABIN2750782
PCSK9 蛋白 PCSK9 · Protein 人, 小鼠, 大鼠 大肠杆菌(E. Coli)
  • WB (Western Blotting: 所列应用)
  • PC (Positive Control: 所列应用)
  • 5 applications
发货至: 中国
ABIN7960091
PCSK9 Protein (D374Y) (His tag) PCSK9 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7944979
PCSK9 Protein (His tag) PCSK9 · Protein 人 大肠杆菌(E. Coli)
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • Imm (Immunogen: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7944981
PCSK9 Protein (His tag) PCSK9 · Protein 人 Mammalian Cells
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • Imm (Immunogen: 所列应用)
  • ELISA (ELISA: 所列应用)
  • 100 μg
  • 1 mg
  • 50 μg
发货至: 中国
ABIN7960087
PCSK9 Protein (His tag) PCSK9 · Protein 小鼠 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
ABIN7960083
PCSK9 Protein (His tag) PCSK9 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 500 μg
发货至: 中国
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • ELISA (ELISA: 所列应用)
  • MS (Mass Spectrometry: 所列应用)
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7313126
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • ELISA (ELISA: 所列应用)
宿主
大鼠
宿主
酵母菌
蛋白类型
Recombinant
纯度
> 90 %
产品编号 ABIN7585446
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • PC (Positive Control: 所列应用)
宿主
人, 小鼠, 大鼠
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN2750782
5 applications
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7960091
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • Imm (Immunogen: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
人
宿主
大肠杆菌(E. Coli)
蛋白类型
Recombinant
产品编号 ABIN7944979
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • WB (Western Blotting: 所列应用)
  • SDS (SDS-PAGE: 所列应用)
  • Imm (Immunogen: 所列应用)
  • ELISA (ELISA: 所列应用)
宿主
人
宿主
Mammalian Cells
蛋白类型
Recombinant
产品编号 ABIN7944981
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
小鼠
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7960087
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
Greater than 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7960083
50 μg (More quantities available)
发货至: 中国
获取报价

Latest Publications for our Proprotein Convertase Subtilisin/kexin Type 9 蛋白

Wang, Amiss, Weidmann, Craik: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." in: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).

Burnap, Sattler, Pechlaner, Duregotti, Lu, Theofilatos, Takov, Heusch, Tsimikas, Fernandez-Hernando, Berry, Hall, Notdurfter, Rungger, Paulweber, Willeit, Kiechl, Levkau, Mayr: "PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).

Chen, Lichtor, Berliner, Chen, Liu: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).

Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

Wijers, Zanoni, Liv, Vos, Jäckstein, Smit, Wilbrink, Wolters, van der Veen, Huijkman, Dekker, Kloosterhuis, van Dijk, Billadeau, Kuipers, Klumperman, von Eckardstein, Kuivenhoven, van de Sluis: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).

Wang, Ghani, Bundock, Weidmann, Harvey, Edwards, Schroeder, Swedberg, Craik: "Calcium-Mediated Allostery of the EGF Fold." in: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).

Grin, Dwivedi, Chathely, Trigatti, Prat, Seidah, Liaw, Fox-Robichaud: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).

Dugardin, Briand, Touche, Schonewille, Moreau, Le May, Groen, Staels, Lestavel: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).

Susan-Resiga, Girard, Kiss, Essalmani, Hamelin, Asselin, Awan, Butkinaree, Fleury, Soldera, Dory, Baass, Seidah: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).

Topchiy, Cirstea, Kong, Boyd, Wang, Russell, Walley: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).

Aliases for Proprotein Convertase Subtilisin/kexin Type 9 蛋白

proprotein convertase subtilisin/kexin type 9 (PCSK9) 蛋白
proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) 蛋白
proprotein convertase subtilisin/kexin type 9 (pcsk9) 蛋白
proprotein convertase subtilisin/kexin type 9 (Pcsk9) 蛋白
AI415265 蛋白
AI747682 蛋白
FH3 蛋白
HCHOLA3 蛋白
LDLCQ1 蛋白
NARC-1 蛋白
NARC1 蛋白
Narc1 蛋白
PC9 蛋白
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