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PPT1 产品

(Palmitoyl-Protein Thioesterase 1 (PPT1))

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The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008].

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Featured PPT1 Categories

PPT1 抗体

High quality antibodies with extensive validation data.

PPT1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PPT1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PPT1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (7)
Cat. No. ABIN1490802
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
  • (5)
Cat. No. ABIN1944801
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN4913200
Quantity 100 μL
Datasheet Datasheet

Recommended PPT1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951472
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN5593926
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1146899
Quantity 96 tests
Datasheet Datasheet

Recommended PPT1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316094
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3086501
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3132137
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PPT1 Products

Sima, Li, Huang, Xu, Beers, Zou, Titus, Ottinger, Marugan, Xie, Zheng: "Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses." in: Orphanet journal of rare diseases, Vol. 13, Issue 1, pp. 54, (2019) (PubMed).

Segal-Salto, Sapir, Reiner: "Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146466, (2016) (PubMed).

Scifo, Szwajda, Soliymani, Pezzini, Bianchi, Dapkunas, Dębski, Uusi-Rauva, Dadlez, Gingras, Tyynelä, Simonati, Jalanko, Baumann, Lalowski: "Quantitative analysis of PPT1 interactome in human neuroblastoma cells." in: Data in brief, Vol. 4, pp. 207-16, (2015) (PubMed).

Mamo, Jules, Dumaresq-Doiron, Costantino, Lefrancois: "The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting." in: Molecular and cellular biology, Vol. 32, Issue 10, pp. 1855-66, (2012) (PubMed).

Calero, Gupta, Nonato, Tandel, Biehl, Hofmann, Clardy: "The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37957-64, (2003) (PubMed).

Weimer, Kriscenski-Perry, Elshatory, Pearce: "The neuronal ceroid lipofuscinoses: mutations in different proteins result in similar disease." in: Neuromolecular medicine, Vol. 1, Issue 2, pp. 111-24, (2002) (PubMed).

Hofmann, Atashband, Cho, Das, Gupta, Lu: "Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2)." in: Current molecular medicine, Vol. 2, Issue 5, pp. 423-37, (2002) (PubMed).

Crews, Lane, Schreiber: "Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 9, pp. 4316-9, (1996) (PubMed).

Schriner, Yi, Hofmann: "cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis." in: Genomics, Vol. 34, Issue 3, pp. 317-22, (1996) (PubMed).

Vesa, Hellsten, Verkruyse, Camp, Rapola, Santavuori, Hofmann, Peltonen: "Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis." in: Nature, Vol. 376, Issue 6541, pp. 584-7, (1995) (PubMed).

Synonyms and alternative names related to PPT1

palmitoyl-protein thioesterase 1 (PPT1), palmitoyl-protein thioesterase 1 (MGYG_00692), palmitoyl-protein thioesterase 1 (Ppt1), Palmitoyl-protein thioesterase 1 (ppt-1), palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) (ppt1), palmitoyl-protein thioesterase 1 L homeolog (ppt1.L), 9530043G02Rik, AA960502, C77813, CLN1, D4Ertd184e, INCL, PPT, Ppt, PPT-1, ppt1, wu:fj17f04, zgc:63969

Protein level used designations for PPT1

  • ceroid-palmitoyl-palmitoyl-protein thioesterase 1
  • palmitoyl-protein hydrolase 1
  • palmitoyl-protein thioesterase 1
  • PPT-1
  • palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
  • palmitoyl protein thioesterase
  • Palmitoyl-protein hydrolase 1
  • palmitoyl-protein thioesterase 1 L homeolog
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