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PPP4C 产品

(Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Categories

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

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Featured PPP4C Categories

PPP4C 抗体

High quality antibodies with extensive validation data.

PPP4C 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PPP4C 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP
Validations
  • (9)
Cat. No. ABIN3022939
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN7260177
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN669261
Quantity 100 μL
Datasheet Datasheet

Recommended PPP4C ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969743
Quantity 96 tests
Datasheet Datasheet

Recommended PPP4C 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316083
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316081
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094741
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PPP4C Products

Williams, Filter, Blake-Hodek, Wadzinski, Fuda, Shalloway, Goldberg: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).

Mourtada-Maarabouni, Williams: "Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells." in: Biochimica et biophysica acta, Vol. 1783, Issue 8, pp. 1490-502, (2008) (PubMed).

Yeh, Yeh, Chuang, Song, Cheng: "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26143-8, (2004) (PubMed).

Mihindukulasuriya, Zhou, Qin, Tan: "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46588-94, (2004) (PubMed).

Zhou, Boomer, Tan: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).

Synonyms and alternative names related to PPP4C

protein phosphatase 4 catalytic subunit (ppp4c), protein phosphatase 4, catalytic subunit a (ppp4ca), protein phosphatase 4 catalytic subunit (PPP4C), protein phosphatase 4, catalytic subunit (Ppp4c), protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S), 1110002D08Rik, AU016079, gc:56413, MGC75928, pp4, PP4, pp4c, PP4C, PP4C-A, pph3, PPH3, PPP4, ppp4c, ppx, PPX, Ppx, wu:fd05e08, zgc:56413

Protein level used designations for PPP4C

  • protein phosphatase 4, catalytic subunit
  • catalytic subunit
  • serine/threonine-protein phosphatase 4 catalytic subunit A
  • PP-X
  • protein phosphatase 4 (formerly X), catalytic subunit
  • protein phosphatase X, catalytic subunit
  • serine/threonine-protein phosphatase 4 catalytic subunit
  • PP4C
  • pp4
  • protein phosphatase X
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