This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008].
Xie, Yang, Chi, Yang, Wang, Xu: "Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study." in: Chinese journal of cancer, Vol. 36, Issue 1, pp. 15, (2017) (PubMed).
Agirre, Román-Gómez, Jiménez-Velasco, Garate, Montiel-Duarte, Navarro, Vázquez, Zalacain, Calasanz, Heiniger, Torres, Minna, Prósper: "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia." in: Oncogene, Vol. 25, Issue 13, pp. 1862-70, (2006) (PubMed).
Liu, Lu, Zhong: "ASPP--Apoptotic specific regulator of p53." in: Biochimica et biophysica acta, Vol. 1756, Issue 1, pp. 77-80, (2005) (PubMed).
Bergamaschi, Samuels, Zhong, Lu: "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation." in: Oncogene, Vol. 24, Issue 23, pp. 3836-41, (2005) (PubMed).
Aliases for PPP1R13B 抗体
protein phosphatase 1 regulatory subunit 13B (PPP1R13B) 抗体 protein phosphatase 1, regulatory subunit 13B (Ppp1r13b) 抗体 protein phosphatase 1 regulatory subunit 13B L homeolog (ppp1r13b.L) 抗体 protein phosphatase 1, regulatory subunit 13Bb (ppp1r13bb) 抗体 protein phosphatase 1 regulatory subunit 13B (ppp1r13b) 抗体 protein phosphatase 1, regulatory (inhibitor) subunit 13B (Ppp1r13b) 抗体 protein phosphatase 1 regulatory subunit 13B (Ppp1r13b) 抗体 AI449786 抗体 ASPP1 抗体 AW545810 抗体 p53BP2-like 抗体 p85 抗体 Tp53bp2 抗体 Trp53bp2 抗体