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Study found that FOXM1 is a target of miR (显示 MLXIP 蛋白)-149. miR (显示 MLXIP 蛋白)-149 inhibited FOXM1 mRNA and protein expression levels by binding to its 3'-UTR in non-small cell lung cancer (NSCLC) cells. Moreover, patients with low expression levels of miR (显示 MLXIP 蛋白)-149 exerted high FOXM1 mRNA levels.
we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B (显示 BUB1B 蛋白) promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B (显示 BUB1B 蛋白) could be a potential therapeutic target for GBM.
MYBL2 (显示 MYBL2 蛋白) is a key downstream factor of Akt (显示 AKT1 蛋白)/FoxM1 signaling to promote progression of human glioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma.
FoxM1 may enhance the invasion and migration of cancer cells, and thus promotes their Epithelialmesenchymal transition, in a mechanism that may involve the regulation of Snai1 (显示 SNAI1 蛋白).
FoxM1 promotes glioma progression by enhancing UBE2C (显示 UBE2C 蛋白) transcription
We found that, compared with the control, the proliferative, migratory and invasive abilities of PC-3 (显示 PCSK1 蛋白) cells were decreased after incubation with different concentrations of TMP . The expression of FOXM1 was decreased in TMP-treated PC-3 (显示 PCSK1 蛋白) cells
FOXM1 expression could be suppressed by miR (显示 MLXIP 蛋白)-216b via direct binding to FOXM1 3'-UTR and miR (显示 MLXIP 蛋白)-216b could inhibit cell proliferation by regulating FOXM1 related Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signal pathway. MiR (显示 MLXIP 蛋白)-216b level is related to prognosis in cervical cancer patients and may serve as a potential prognostic marker.
Results revealed that FoxM1 protein was highly expressed in HSCC tissues and that its high expression was closely associated with HSCC tumor differentiation (P=0.004), tumor size (P=0.002), clinical stage (P=0.001), lymph node metastasis (P=0.002), treatment (P=0.045) and expression of the proliferation marker Ki-67 (显示 MKI67 蛋白) (P<0.001).
Findings suggest that FoxM1 promotes the EMT (显示 ITK 蛋白), invasion and migration of TSCC cells, and cross-talks with c-Met/AKT (显示 AKT1 蛋白) signaling to form a positive feedback loop to promote TSCC development.
The suppressive activity of miR216b in glioma, which is largely ascribed to downregulation of FoxM1.
Upregulated ROS (显示 ROS1 蛋白) induced by FABP4 (显示 FABP4 蛋白) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) and the Kras/ERK (显示 EPHB2 蛋白)/Foxm1 pathways are essential to restrict SOX9 (显示 SOX9 蛋白) expression in basal cells during pulmonary branching morphogenesis
YAP (显示 YAP1 蛋白) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (显示 TNNI3 蛋白) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (显示 INS 蛋白)-FoxM1/PLK1/CENP-A (显示 CENPA 蛋白) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (显示 EGF 蛋白) promotes FoxM1 expression through the ERK (显示 EPHB2 蛋白) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (显示 PIK3CG 蛋白)-selective inhibitor and in Pik3cg (显示 PIK3CG 蛋白)(-/-) mice after LPS (显示 TLR4 蛋白) challenge. Defective vascular repair in Pik3cg (显示 PIK3CG 蛋白)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (显示 HOXA10 蛋白) and cyclin D3 (显示 CCND3 蛋白).
FOXM1 and CENPF (显示 CENPF 蛋白) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (显示 TP53 蛋白) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead box protein M1
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, INS-1 winged helix
, forkhead box M1
, forkhead box protein M1-like
, forkhead homolog 16
, winged-helix transcription factor Trident