Use your antibodies-online credentials, if available.
LmnA (显示 LMNA 蛋白) binds AIMP3 via its extreme C-terminus. Together these findings provide a structural insight for understanding the interaction between AIMP3 and LmnA (显示 LMNA 蛋白) in AIMP3 degradation.
analysis of the heterotetrameric complex structure of the glutathione transferase (GST (显示 SLCO6A1 蛋白)) domains shared among the four MSC (显示 MSC 蛋白) components, methionyl-tRNA synthetase (显示 MARS 蛋白) (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS (显示 EPRS 蛋白)), AIMP2 (显示 AIMP2 蛋白) and AIMP3
AIMP3 was shown to be involved in the cellular aging of human mesenchymal stem cells.
Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway.
AIMP3 stabilizes and protects methionyl-tRNA synthetase (显示 MARS 蛋白) and eIF2gamma (显示 EIF2S3 蛋白) through the binding interactions.
AIMP3 is a critical mediator of Met-tRNA(i)(Met) transfer from methionyl-tRNA synthetase (显示 MARS 蛋白) to eIF2 (显示 EIF2S1 蛋白) complex for the accurate and efficient translation initiation
Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (显示 HSPB3 蛋白) (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (显示 HSPB3 蛋白) (AIMP3) by UV irradiation-induced stress.
Decreased expression of AIMP3 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC (显示 CALR 蛋白).
p18 (显示 CDKN2C 蛋白) is a haploinsufficient tumor suppressor and a key factor for ATM (显示 ATM 蛋白)/ATR (显示 ANTXR1 蛋白)-mediated p53 (显示 TP53 蛋白) activation.
analysis of the three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with
AIMP3 is a specific regulator of mature lamin A (显示 LMNA 蛋白) and imply that enhanced expression of AIMP3 might be a factor driving cellular and/or organismal aging [AIMP3]
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
eukaryotic translation elongation factor 1 epsilon 1
, eukaryotic translation elongation factor 1 epsilon-1
, ARS-interacting multifunctional protein 3
, aminoacyl tRNA synthetase complex-interacting multifunctional protein 3
, multisynthase complex auxiliary component p18
, p18 component of aminoacyl-tRNA synthetase complex
, elongation factor p18
, multisynthetase complex auxiliary component p18
, Elongation factor p18
, Multisynthase complex auxiliary component p18