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Human Polyclonal BRCC3 Primary Antibody for IHC, ELISA - ABIN1001938
Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003
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Human Polyclonal BRCC3 Primary Antibody for IHC (p), WB - ABIN2477712
Poulter: Management of multiple risk factors for coronary heart disease in patients with hypertension. in American heart journal 1991
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In late S/G2 (显示 STRN3 抗体) phase, the DNA damage-responsive E3 ligase RNF8 (显示 RNF8 抗体) conjugates K63-linked ubiquitin chains to tankyrase 1 (显示 TNKS 抗体), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (显示 FAM175B 抗体)/BRCC36-containing deubiquitinase complex.
findings uncover a pivotal role of BRCC36 DUB in limiting DSB processing and repair and illustrate how cells may physically couple ubiquitin recognition and metabolizing activities for fine tuning of DNA repair processes.
BRCC3 may play a role in B7-H3 (显示 CD276 抗体)-induced 5-Fu resistance.
BRCC3 inversely correlated with NPC (显示 NPC1 抗体) overall and relapse-free survival. Its expression was higher in radioresistant NPC (显示 NPC1 抗体) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.
BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.
KIAA0157 (显示 FAM175B 抗体) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.
upregulation of BRCC3 expression is associated with glioma.
these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.
NBA1/MERIT40 (显示 BABAM1 抗体) and BRE (显示 BRE 抗体) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes
scaffold proteins not only participate in the regulation of BRCC36 activity but also determine its subcellular localization and cellular functions.
The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (显示 NLRP3 抗体) activity by promoting its deubiquitination.
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
BRCA1/BRCA2-containing complex, subunit 3
, BRCA1-A complex subunit BRCC36
, BRCA1/BRCA2-containing complex subunit 3
, BRCA1/BRCA2-containing complex subunit 36
, BRISC complex subunit BRCC36
, lys-63-specific deubiquitinase BRCC36
, 6.1A protein