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These data suggest that Schistosoma japonicum Sjp40 might inhibit hepatic stellate cell activation by promoting cellular senescence via SKP2/P27 (显示 PAK2 蛋白) signaling pathway.
human epidermal growth factor receptor (显示 EGFR 蛋白) 2 (HER-2 (显示 ERBB2 蛋白)) levels, were correlated well with TSP50 (显示 PRSS50 蛋白)/p-Samd2 (显示 SARM1 蛋白)/3 and TSP50 (显示 PRSS50 蛋白)/p27 (显示 PAK2 蛋白) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (显示 PRSS50 蛋白)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
Furthermore, inhibition of COPS5 (显示 COPS5 蛋白) resulted in an elevation of Akt (显示 AKT1 蛋白) expression and sensitized SOC (显示 UBXN11 蛋白) cells to Akt (显示 AKT1 蛋白) inhibitor MK2206. Suppression of COPS5 (显示 COPS5 蛋白) and Akt (显示 AKT1 蛋白) offers a potential strategy for the treatment of SOC (显示 UBXN11 蛋白).
Loss of p27 (显示 PAK2 蛋白) associated with risk for endometrial carcinoma arising in the setting of obesity.
p53 (显示 TP53 蛋白) immunopositivity was more frequent in SCC (显示 CYP11A1 蛋白) (65%) than in VC (23%) (P=0.001). VC had lower p53 (显示 TP53 蛋白) as compared with well-differentiated SCC (显示 CYP11A1 蛋白) and SCC (显示 CYP11A1 蛋白) without lymph node metastasis. No significant difference was seen in pRb (显示 RB1 蛋白), p16, and p27 (显示 PAK2 蛋白) expression
The PSMD9 intronic SNPs rs74421874 (IVS3+nt460 G>A) and rs3825172 (IVS3+nt437 C>T) remain significantly associated with insomnia only when taking into account anxiety -and not depression- as covariate.
Studies have found significant associations of the treatment response with the 26S proteasome non-ATPase subunit (显示 PSMD14 蛋白) 9 (显示 ATP5G1 蛋白) (PSMD9), proteasome alpha type 7 (显示 PSMA7 蛋白) subunit (PSMA7 (显示 PSMA7 蛋白)) and PSMD13 (显示 PSMD13 蛋白) genes.
recurrence rate of p27 and/or PTEN-negative patients was higher than that of the positive ones,that should be followed up closely after treatment
The present study provided the first evidences that miR (显示 MLXIP 蛋白)-1470 mediated lapatinib induced p27 (显示 PAK2 蛋白) upregulation by targeting c-jun (显示 JUN 蛋白).
Staining intensities of cell cycle inhibitors p27 (显示 PAK2 蛋白) and p57 (显示 CDKN1C 蛋白) significantly increased in all parts of preeclamptic placentas compared to control
These results therefore suggest that proteasomes, particularly p27 (显示 CDKN1B 蛋白) subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene.
26S proteasome non-ATPase regulatory subunit 9
, 26S proteasome regulatory subunit p27
, homolog of rat Bridge 1
, proteasome 26S non-ATPase regulatory subunit 9
, transactivating protein Bridge-1
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
, proteasome 26S non-ATPase subunit 9
, PDZ domain-containing protein