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TNPO1-mediated nuclear import may constitute a novel input pathway of how cellular redox state signals to the clock, since redox stress increases binding of TNPO1 to PER1 (显示 PER1 蛋白) and decreases its nuclear localization. TNPO1 is one of the novel players essential for normal circadian periods and potentially for redox regulation of the clock.
A molecular docking and dynamics study concluded that R521C and R521H mutations in FUS (显示 FUS 蛋白) result in weak binding with Karyopherin-beta2 leading to amyotrophic lateral sclerosis.
Data suggest that micoRNA-128 targets the 3prime-untranslated region of nuclear import factor transportin 1 (TNPO1) mRNA.
the TNPO1-Rab8 (显示 RAB8A 蛋白)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
Together, these results indicate that transportin-1 mediates YB-1 (显示 YBX1 蛋白) nuclear translocation.
findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function
Importins, Impbeta, Kapbeta2, Imp4 (显示 SPPL2B 蛋白), Imp5 (显示 IPO5 蛋白), Imp7 (显示 IPO7 蛋白), Imp9 (显示 IPO9 蛋白), and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 (显示 IPO5 蛋白) with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (显示 HIST3H3 蛋白) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (显示 ALDH1A2 蛋白)).
FGF2 (显示 FGF2 蛋白) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (显示 RAN 蛋白) in human glioblastoma cells
Kapbeta2 interacts with ULK2 (显示 ULK2 蛋白) through ULK2 (显示 ULK2 蛋白)'s putative PY-NLS (显示 ALDH1A2 蛋白) motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity.
Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (显示 RAB23 蛋白) exists in a complex with Kif17 (显示 KIF17 蛋白) and importin b2 implying that Kif17 (显示 KIF17 蛋白) needs to bind to regulatory proteins like Rab23 (显示 RAB23 蛋白) for its ciliary transport
Association with Tnpo1 is necessary for Oxtr (显示 OXTR 蛋白) nuclear localization. This is required for Oxt (显示 OXT 蛋白)-induced osteoblast differentiation. osteoblast differentiation.
DJ-1 (显示 PARK7 蛋白) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (显示 HTT 蛋白) protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
Results indicate that TRN1 positively regulates miRNA activity by promoting the association of miRNAs with AGO1 (显示 EIF2C1 蛋白), and they reveal opposing roles of two importin beta (显示 KPNB1 蛋白) family proteins in miRNA loading.
Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
M9 region interaction protein
, importin 2
, importin beta 2
, importin beta-2
, karyopherin (importin) beta 2
, karyopherin beta-2
, transportin 1
, myocardial ischemic preconditioning up-regulated protein 1
, myocardial ischemic preconditioning upregulated 1