PIK3R5 产品
(Phosphoinositide-3-Kinase, Regulatory Subunit 5 (PIK3R5))
Categories
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011].
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Featured PIK3R5 Categories
Recommended PIK3R5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1500211
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1500212
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (4)
Cat. No.
ABIN2786003
Quantity
100 μL
Datasheet
Datasheet
Recommended PIK3R5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7563846
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7554988
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315090
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our PIK3R5 Products
: "Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer." in: Cancer research and treatment : official journal of Korean Cancer Association, (2018) (PubMed).: "A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia." in: Human mutation, Vol. 33, Issue 2, pp. 351-4, (2012) (PubMed).
: "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma." in: The Journal of cell biology, Vol. 160, Issue 1, pp. 89-99, (2003) (PubMed).
: "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 762-70, (1996) (PubMed).
: "Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin." in: Nature, Vol. 372, Issue 6506, pp. 570-3, (1995) (PubMed).
: "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest." in: Genes & development, Vol. 8, Issue 1, pp. 9-22, (1994) (PubMed).
Synonyms and alternative names related to PIK3R5
phosphoinositide-3-kinase regulatory subunit 5 (PIK3R5), phosphoinositide-3-kinase regulatory subunit 5 S homeolog (pik3r5.S), phosphoinositide-3-kinase, regulatory subunit 5 (Pik3r5), phosphoinositide-3-kinase regulatory subunit 5 (Pik3r5), AV230647, F730038I15Rik, FOAP-2, p101, P101, P101-PI3K, RGD1563261Protein level used designations for PIK3R5
- PI3-kinase regulatory subunit 5
- phosphoinositide-3-kinase, regulatory subunit 5, p101
- PI3-kinase p101 subunit
- phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
- phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
- phosphoinositide 3-kinase regulatory subunit 5
- protein FOAP-2
- ptdIns-3-kinase p101
- Phosphoinositide 3-kinase regulatory subunit 5
- IB PI3-kinase p101 subunit
- p101-PI3K
- ptdIns-3-kinase regulatory subunit
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