PHLPP2 抗体
(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
Recommended next Filters:
您想试用我们的人工智能搜索吗？
17 results
Latest Publications for our PHLPP2 抗体
: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Aliases for PHLPP2 抗体
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) 抗体PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (phlpp2) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 抗体
AI481772 抗体
C130044A18Rik 抗体
PHLPPL 抗体
phlppl 抗体
Phlppl 抗体
RGD1562857 抗体
您还需要查找其他产品吗？
- PHLPP1 抗体
- PHLDB2 抗体
- PHLDB1 抗体
- PHLDA3 抗体
- PHLDA2 抗体
- PHLDA1 抗体
- PHKG2 抗体
- PHKG1 抗体
- PHKB 抗体
- PHKA2 抗体
- PHKA1 抗体
- PHIP 抗体
- PHGDH 抗体
- PHF8 抗体
- PHF7 抗体
- PHF6 抗体
- PHF5A 抗体
- PHF23 抗体
- PHF21A 抗体
- PHF20L1 抗体
- Phosducin 抗体
- Phosducin-Like 抗体
- Phosphatase and Actin Regulator 3 抗体
- Phosphatase and Actin Regulator 4 抗体
- Phosphatase and Tensin Homolog 抗体
- Phosphate Cytidylyltransferase 1, Choline, alpha 抗体
- Phosphate Cytidylyltransferase 1, Choline, beta 抗体
- Phosphatidylinositol Binding clathrin Assembly Protein 抗体
- Phosphatidylinositol Phosphate 抗体
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta 抗体
- PHOSPHO1 抗体
- PHOSPHO2 抗体
- phosphoenolpyruvate Carboxykinase 1 (Soluble) 抗体
- phosphofructokinase, Muscle 抗体
- Phosphoglucomutase 1 抗体
- Phosphoglucomutase 2 抗体
- Phosphoglucomutase 3 抗体
- Phosphoglucomutase 5 抗体
- phosphoglycerate Mutase 1 (Brain) 抗体
- Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide 抗体
You are here:
