PHLPP1 抗体
(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
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28 results :
PHLPP1
适用: 人, 小鼠, 大鼠
WB, ELISA
宿主: 兔
Polyclonal
unconjugated
1 image
1 reference
Latest Publications for our PHLPP1 抗体
: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." in: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).
: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." in: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).
: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).
: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).
: "Cell-type-specific regulation of raft-associated Akt signaling." in: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).
: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." in: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).
: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).
: "Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt ..." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22155-65, (2009) (PubMed).
: "Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 15215-23, (2009) (PubMed).
Aliases for PHLPP1 抗体
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) 抗体PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) 抗体
PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) 抗体
AI836256 抗体
mKIAA0606 抗体
PHLPP 抗体
Phlpp 抗体
PLEKHE1 抗体
Plekhe1 抗体
SCOP 抗体
Scop 抗体
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