Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA (By similarity).
Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: "Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex." in: The Journal of biological chemistry, Vol. 289, Issue 42, pp. 28956-70, (2014) (PubMed).
Strobl-Mazzulla, Bronner: "A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition." in: The Journal of cell biology, Vol. 198, Issue 6, pp. 999-1010, (2012) (PubMed).
Aliases for PHF12 抗体
PHD finger protein 12 (PHF12) 抗体 PHD finger protein 12 (phf12) 抗体 PHD finger protein 12 S homeolog (phf12.S) 抗体 PHD finger protein 12 (Phf12) 抗体 2410142K10Rik 抗体 F630045O13 抗体 mKIAA1523 抗体 PF1 抗体