The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. [provided by RefSeq, Jul 2008].
Park, Park, Lee, Kim, Kim, Jung, Shim, Choi, Park, Cho, Kim: "Effect of FGF-2 on Collagen Tissue Regeneration by Human Vertebral Bone Marrow Stem Cells." in: Stem cells and development, (2014) (PubMed).
Park, Park, Kim, Lee, Kim, Jung, Park, Jeon, Cho, Kim: "Differential Effect of Water-Soluble Chitin on Collagen Synthesis of Human Bone Marrow Stem Cells and Human Periodontal Ligament Stem Cells." in: Tissue engineering. Part A, (2014) (PubMed).