Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3) Peptide
UBE2L3
适用: 人
宿主: 合成
BP, IHC, WB
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- 抗原 See all UBE2L3 products
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-UBE2L3 antibody (Catalog #: ARP43025_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
- 别名
- E2-F1 Peptide, L-UBC Peptide, UBCH7 Peptide, UbcM4 Peptide, C79827 Peptide, Ubce7 Peptide, ube2l3 Peptide, wu:fc22h11 Peptide, zgc:86727 Peptide, UBE2L3 Peptide, ube2l3l Peptide, wu:fb38h03 Peptide, ubiquitin conjugating enzyme E2 L3 Peptide, ubiquitin-conjugating enzyme E2L 3 Peptide, ubiquitin-conjugating enzyme E2L 3a Peptide, ubiquitin conjugating enzyme E2 L3 S homeolog Peptide, ubiquitin-conjugating enzyme E2L 3b Peptide, UBE2L3 Peptide, Ube2l3 Peptide, ube2l3a Peptide, ube2l3.S Peptide, ube2l3b Peptide
- 背景
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Alias Symbols: E2-F1, L-UBC, UBCH7, UbcM4
Protein Interaction Partner: UBE3A,ARIH1,ARIH2,BRCA1,CBL,CCNB1IP1,CUL9,NEDD4,NEDD4L,PARK2,PTEN,RNF144A,RNF144B,RNF19A,RNF216,SMAD4,UBE3A,UBOX5,ARIH1,ARIH1,ARIH2,ARIH2,AURKA,BRCA1,CBL,CBL,CUL9,EIF4E2,ITCH,NEDD4,POLR2A,PTEN,RNF19A,RNF216,RSP5,SMURF2,UBASH3A,UBE3A,UBOX5,Ubox5,WWP2
Protein Size: 668 - 分子量
- 75 kDa
- 基因ID
- 7332
- NCBI登录号
- NM_004739, NP_003338
- UniProt
- P68036
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