This is a synthetic peptide designed for use in combination with anti-UBA1 antibody (Catalog #: ARP58687_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Protein Interaction Partner: CDK1,GAN,HSPH1,MGMT,SEMA3F,TAF9,TMCC2,TSSC4,BARD1,BRCA1,BTRC,CBL,DZIP3,FANCD2,HGS,HSPH1,NEDD4,NEDD4L,POLR2A,RBCK1,STUB1,UBC