Signal Transducer and Activator of Transcription 5A (STAT5A) Peptide
STAT5A
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all STAT5A products
- STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-STAT5A antibody (Catalog #: ARP38256_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
- 别名
- MGF Peptide, STAT5 Peptide, AA959963 Peptide, Stat5 Peptide, STAT5A/MGF Peptide, STATA5 Peptide, STAT5A Peptide, stat5 Peptide, stat5b Peptide, signal transducer and activator of transcription 5A Peptide, signal transducer and activator of transcription 5a Peptide, STAT5A Peptide, Stat5a Peptide, stat5a Peptide, LOC100348518 Peptide, LOC100716811 Peptide
- 背景
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STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGF, STAT5
Protein Interaction Partner: CCND2,ESR1,IL5,IL9,NMI,STAT5A,BMX,BRCA1,BRCA2,BTK,CBL,CCR5,CD247,CEBPB,CENPJ,CRK,CRKL,CTLA4,EGFR,EP300,EPOR,ERBB4,ESR1,ESR2,GHR,IL2RB,IL2RG,IL7R,INSR,JAK1,JAK2,JAK3,KIT,LCK,MAGEA12,MAPK1,MAPK3,NCOR2,NMI,NR3C1,PDGFRA,PDGFRB,POU2F1,PPIB,PPP2CA,PRTFDC1,PTPN1,PTPN11,PTPN2,SHC1,SRC,STAP2,STAT1,STAT3,STAT5A,STAT5B,SYK,TEK,TSLP,BRCA1,BRCA2,CD247,CRKL,EGFR,EPOR,ERBB4,ESR1,ESR2,IL2RB,JAK1,JAK2,JAK3,MAGEA12,MAPK1,NMI,PRTFDC1,PTPN1,PTPN11,SHC1
Protein Size: 794 - 分子量
- 91 kDa
- 基因ID
- 6776
- NCBI登录号
- NM_003152, NP_003143
- UniProt
- P42229
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