Splicing Factor 3a, Subunit 1 (SF3A1) Peptide
SF3A1
适用: 人
宿主: 合成
BP, WB, IHC, IF
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- 抗原 See all SF3A1 products
- SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-SF3A1 antibody (Catalog #: ARP40615_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))
- 别名
- Dmel\\CG16941 Peptide, SF3a1 Peptide, SF3a120 Peptide, DDBDRAFT_0168938 Peptide, DDBDRAFT_0233180 Peptide, DDB_0168938 Peptide, DDB_0233180 Peptide, 1200014H24Rik Peptide, 5930416L09Rik Peptide, AI159724 Peptide, si:dz150f13.2 Peptide, wu:fc38e01 Peptide, wu:fc50a11 Peptide, wu:fj37c05 Peptide, zgc:65786 Peptide, PRP21 Peptide, PRPF21 Peptide, SAP114 Peptide, SF3A120 Peptide, CG16941 gene product from transcript CG16941-RA Peptide, SWAP/Surp domain-containing protein Peptide, splicing factor 3a, subunit 1 Peptide, splicing factor 3a subunit 1 Peptide, CG16941 Peptide, sf3a1 Peptide, spl1 Peptide, Sf3a1 Peptide, SF3A1 Peptide
- 背景
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SF3A1 is the subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRP21, PRPF21, SAP114, SF3A120
Protein Interaction Partner: SF3A2,SF3A3,SF3A2,SF3A3,SMAD3,SMURF1,SP1,TCERG1,ATG12,CDC5L,NCOR1,PRP11,PRP9,RAE1,SF3A2,SF3A3,TCEA1,TCERG1,USP30
Protein Size: 793 - 分子量
- 89 kDa
- 基因ID
- 10291
- NCBI登录号
- NM_005877, NP_005868
- UniProt
- Q15459
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