Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (N-Term) Peptide
PSMD10
适用: 小鼠
宿主: 合成
BP, WB
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- 抗原 See all PSMD10 products
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- 蛋白结构域
- N-Term
- 宿主
- 小鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- KERILADKSL ATRTDQDSRT ALHWACSAGH TEIVEFLLQL GVPVNDKDDA
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Psmd10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- 别名
- gankyrin Peptide, zgc:109707 Peptide, dJ889N15.2 Peptide, p28 Peptide, p28(GANK) Peptide, AW554874 Peptide, p28Gank Peptide, proteasome 26S subunit, non-ATPase 10 Peptide, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Peptide, psmd10 Peptide, PSMD10 Peptide, Psmd10 Peptide
- 背景
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Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
Alias Symbols: AW554874
Protein Size: 231 - 分子量
- 25 kDa
- 基因ID
- 53380
- NCBI登录号
- NM_016883, NP_058579
- UniProt
- Q9Z2X2
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