Perforin 1 (Pore Forming Protein) (PRF1) Peptide
PRF1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all Perforin 1 (PRF1) products
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PRF1 antibody (Catalog #: ARP42208_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- 别名
- FLH2 Peptide, HPLH2 Peptide, P1 Peptide, PFN1 Peptide, PFP Peptide, PRF1 Peptide, Pfn Peptide, Pfp Peptide, Prf-1 Peptide, Cyta Peptide, RATCYTA Peptide, LOC443187 Peptide, perforin Peptide, prf1 Peptide, cytolysin Peptide, perforin-1 Peptide, perforin-1-like Peptide, perforin 1 Peptide, perforin 1 (pore forming protein) Peptide, perforin Peptide, perforin 1 L homeolog Peptide, PRF1 Peptide, Prf1 Peptide, LOC443187 Peptide, prf1 Peptide, prf1.L Peptide
- 背景
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PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: CALR,DDX24,GZMB,CALR
Protein Size: 555 - 分子量
- 59 kDa
- 基因ID
- 5551
- NCBI登录号
- NM_005041, NP_005032
- UniProt
- P14222
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