Polymerase (DNA Directed) iota (POLI) (N-Term) Peptide
POLI
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all POLI products
- POLI (Polymerase (DNA Directed) iota (POLI))
- 蛋白结构域
- N-Term
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- PVVERLGFDE NFVDLTEMVE KRLQQLQSDE LSAVTVSGHV YNNQSINLLD
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-POLI Antibody(ARP52299_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- POLI (Polymerase (DNA Directed) iota (POLI))
- 别名
- poli Peptide, wu:fc27h11 Peptide, zgc:110185 Peptide, GB12093 Peptide, NV16187 Peptide, RAD30B Peptide, RAD3OB Peptide, Rad30b Peptide, DNA polymerase iota Peptide, polymerase (DNA directed) iota Peptide, polymerase (DNA directed), iota Peptide, POLI Peptide, poli Peptide, LOC551219 Peptide, AFUA_4G11140 Peptide, LOC5568276 Peptide, Pol-iota Peptide, Poli Peptide
- 背景
-
POLI is an error-prone DNA polymerase specifically involved in DNA repair.POLI plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.POLI favors Hoogsteen base-pairing in the active site.POLI inserts the correct base with high-fidelity opposite an adenosine template.POLI exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine.POLI may play a role in hypermutation of immunogobulin genes.POLI forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Alias Symbols: RAD30B, RAD3OB
Protein Interaction Partner: REV1,CALCOCO2,DAZAP2,DVL2,PCNA,POLH,REV1,RNF11,UBA52,UBB,CALCOCO2,DAZAP2,DVL2
Protein Size: 740 - 分子量
- 83 kDa
- 基因ID
- 11201
- NCBI登录号
- NM_007195, NP_009126
- UniProt
- Q9UNA4
-
You are here:
