Promyelocytic Leukemia (PML) Peptide
PML
适用: 人
宿主: 合成
BP, WB, IHC
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- 抗原 See all PML products
- PML (Promyelocytic Leukemia (PML))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PML antibody (Catalog #: ARP33048_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PML (Promyelocytic Leukemia (PML))
- 别名
- MYL Peptide, PP8675 Peptide, RNF71 Peptide, TRIM19 Peptide, 1200009E24Rik Peptide, AI661194 Peptide, Trim19 Peptide, RGD1562602 Peptide, PML Peptide, promyelocytic leukemia Peptide, PML Peptide, Pml Peptide
- 背景
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PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus.
Alias Symbols: MYL, PP8675, RNF71, TRIM19
Protein Interaction Partner: AURKA,ATR,MDM2,MYC,RPL11,SMAD2,SMAD3,TGFBR1,TGFBR2,ZFYVE9,ANKRD2,ARID3A,ARNT,AURKA,BCL2,CCNT1,CHFR,CREBBP,CSNK2A1,DAXX,EIF4E,ELF4,EP300,GATA2,HDAC1,HDAC2,HDAC3,HHEX,MAPK14,MDM2,MXD1,MYB,MYC,NCOR1,NCOR2,NR4A1,PAWR,PAXIP1,PML,RARA,RB1,RELA,RPL11,SENP2,SIN3A,SKI,SMAD3,SP1,SRF,STAT3,SUMO1,SUMO2,SUMO3,SUV39H1,TDG,TGFBR1,TGFBR2,THRA,TOPBP1,TP53,TP73,TRIM24,TRIM27,TRIM69,ZBTB16,ZFYVE9,ANKRD2,ARNT,ATF2,BCL6,CCNT1,CHFR,CHFR,CREBBP,DAXX,EIF4E,FOS,GATA2,HDAC1,HDAC2,HDAC3,HHEX,JUN,MAPK11,MDM2,MYB,NCOR1,NCOR2,NR4A1,PLAGL1,PML,RARA,RB1,RELA,RPL11,RXRA,SIN3A,SKI,SMAD2,SMAD3,SP1,SRF,STAT3,SUMO1,Senp2,TDG,TOPBP1,TP53,TRIM24,TRIM27,TRIM69,UBC,UBE2I,ZBTB16,ZFYVE9
Protein Size: 540 - 分子量
- 59 kDa
- 基因ID
- 5371
- UniProt
- P29590, A4VCI9
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