NR1D2
(Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
产品特性
This is a synthetic peptide designed for use in combination with anti-NR1D2 antibody (Catalog #: ARP38568_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
浓度
1 mg/mL
缓冲液
Final peptide concentration is 1 mg/mL in PBS.
注意事项
Avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
抗原
NR1D2
(Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2))
别名
BD73 Peptide, EAR-1R Peptide, RVR Peptide, HZF-2 Peptide, Rev-erb Peptide, REV-ERBB Peptide, NR1D2 Peptide, rvr Peptide, bd73 Peptide, hzf2 Peptide, ear-1r Peptide, hs.37288 Peptide, NR1D2-A Peptide, Reverbbeta-A Peptide, reverbb1 Peptide, reverbb Peptide, reverbb2 Peptide, zgc:92019 Peptide, nuclear receptor subfamily 1 group D member 2 Peptide, nuclear receptor subfamily 1, group D, member 2 Peptide, nuclear receptor subfamily 1, group D, member 2a Peptide, nuclear receptor subfamily 1, group D, member 2b Peptide, NR1D2 Peptide, Nr1d2 Peptide, nr1d2 Peptide, nr1d2a Peptide, nr1d2b Peptide
背景
NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3' and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis.
Alias Symbols: RVR, BD73, EAR-1R
Protein Interaction Partner: CUL1,NCOA5,NCOR1,NR1D1,RGN,UBE2I,NCOR1