NFKB1
(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))
蛋白结构域
Middle Region
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
产品特性
This is a synthetic peptide designed for use in combination with anti-NFKB1 antibody (Catalog #: AVARP09048_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interaction Partner: BCL3,BCL3,BIRC3,CD82,CTNNB1,IL8,KAT5,NCOA1,NFKB1,NFKB1,NFKBIA,RELA,RELA,RUVBL2,SPAG9,AR,ATF3,BCL3,BRCA1,BTRC,CDK9,CEBPB,CFLAR,CHUK,CTNNB1,E2F1,ELF1,ELF3,ESR1,ETS1,FBXW11,FOS,G3BP2,GSK3B,HDAC1,HMGA2,HMGB1,IKBKB,IKBKG,IL2RA,IRF1,IRF2,ITGB3BP,KAT5,KLF5,KPNA3,LYL1,MAP3K8,MEN1,MTPN,NCF1,NCOA1,NCOR2,NFKB1,NFKB2,NFKBIA,NFKBIB,NFKBIE,NFKBIZ,NFRKB,NKRF,NOTCH1,NR3C1,PARP1,PDCD11,PPP4C,PRKACA,REL,RELA,RELB,RIPK1,RSF1,RXRA,SPAG9,SPI1,STAT3,STAT6,TNFSF11,TNIP2,TP53BP1,TRIP4,TSC22D3,TXN,UBE2D3,UBE2K,UNC5CL,BCL3,BTRC,CEBPB,CHUK,COPB2,E2F1,ELF1,ELF3,GSK3B,HDAC1,HMGA2,HMGB1,IKBKB,IKBKG,IRF2,IRF8,IRF9,ITGB3BP,KLF5,KPNA3,LYL1,MAP3K8,MEN1,MTPN,NCOA1,NCOA6,NCOR1,NFKB1,NFKB2,NFKBIA,NFKBIE,NFKBIZ,NKRF,NOTCH1,NR3C1,PPP4C,REL,RELA,RELB,RSF1,RXRA,SP1,SPAG9,STAT3,STAT6,TAB2,TBK1,TNIP2,TNIP3,TP53BP1,TSC22D3,TXN,UNC5CL