E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) (Middle Region) Peptide
NEDD4L
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all NEDD4-2 (NEDD4L) products
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-NEDD4L antibody (Catalog #: ARP43192_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- 别名
- NEDD4-2 Peptide, NEDD4.2 Peptide, RSP5 Peptide, hNEDD4-2 Peptide, nedd4 Peptide, nedd4-2 Peptide, NEDD4 Peptide, Nedd4-2 Peptide, 1300012C07Rik Peptide, Nedd4b Peptide, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Peptide, NEDD4L Peptide, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog Peptide, neural precursor cell expressed, developmentally down-regulated gene 4-like Peptide, NEDD4L Peptide, LOC776799 Peptide, nedd4l.S Peptide, Nedd4l Peptide
- 背景
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NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Alias Symbols: FLJ33870, KIAA0439, RSP5, hNedd4-2, NEDD4-2, NEDD4.2, hNEDD4-2
Protein Interaction Partner: HHV4gp002,ARHGDIA,LAPTM5,NDFIP2,NTRK1,RNF11,SCN5A,SCNN1A,SCNN1B,SCNN1G,SGK1,UBE2E1,UBE2L3,AMOT,ARHGDIA,NEDD4L,NR3C1,SCNN1A,SCNN1B,SCNN1G,SFN,UBA1,UBC
Protein Size: 955 - 分子量
- 110 kDa
- 基因ID
- 23327
- NCBI登录号
- NM_015277, NP_056092
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