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Myeloid Cell Nuclear Differentiation Antigen (MNDA) Peptide

MNDA 适用: 人 宿主: 合成 BP, WB
产品编号 ABIN980169
发货至: 中国
  • 抗原 See all MNDA products
    MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))
    宿主
    资源
    • 3
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-MNDA antibody (Catalog #: ARP38152_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))
    别名
    PYHIN3 Peptide, A730048F03 Peptide, Ifi205b Peptide, myeloid cell nuclear differentiation antigen Peptide, interferon activated gene 211 Peptide, MNDA Peptide, Ifi211 Peptide
    背景
    The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

    Alias Symbols: PYHIN3

    Protein Interaction Partner: CDK1,CDK2,HOXB2,RB1,RBL2,TP53

    Protein Size: 407
    分子量
    46 kDa
    基因ID
    4332
    NCBI登录号
    NM_002432, NP_002423
    UniProt
    P41218
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