Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (N-Term) Peptide
MAP4K4
适用: 人
宿主: 合成
BP, IHC, WB
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- 抗原 See all MAP4K4 products
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-MAP4K4 antibody (Catalog #: ARP49031_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- 别名
- FLH21957 Peptide, HGK Peptide, MEKKK4 Peptide, NIK Peptide, 9430080K19Rik Peptide, AU043147 Peptide, AU045934 Peptide, AW046177 Peptide, Nik Peptide, mitogen-activated protein kinase kinase kinase kinase 4 Peptide, MAP4K4 Peptide, Map4k4 Peptide
- 背景
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MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK, MEKKK4
Protein Interaction Partner: DOK1,GBP3,ITGB1,MAP3K7,NCK1,RAP2A,RASA1,SLC9A1,ATL1,BRCA1,GBP3,ITGB1,MAP3K1,MAP3K7,NCK1,RASA1,ZRANB1
Protein Size: 1166 - 分子量
- 133 kDa
- 基因ID
- 9448
- NCBI登录号
- NM_004834, NP_004825
- UniProt
- O95819
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