Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (N-Term) Peptide
ITGB3BP
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all ITGB3BP products
- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-ITGB3BP antibody (Catalog #: ARP54999_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
- 别名
- CENP-R Peptide, CENPR Peptide, HSU37139 Peptide, NRIF3 Peptide, TAP20 Peptide, 4930471O16Rik Peptide, AU022583 Peptide, integrin subunit beta 3 binding protein Peptide, integrin beta 3 binding protein (beta3-endonexin) Peptide, ITGB3BP Peptide, Itgb3bp Peptide
- 背景
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ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
Protein Interaction Partner: MTA1,ARFIP2,CCNA2,COL4A3BP,DDX24,ESR1,ITGB3,ITGB3BP,ITGB5,MTA1,NFKB1,RECQL5,RXRA,ARFIP2,CCNA2,COL4A3BP,DDX24,ITGB3,ITGB3BP,ITGB5,NFKB1,RECQL5,RELA,RXRA,RXRG,THRA
Protein Size: 177 - 分子量
- 20 kDa
- 基因ID
- 23421
- NCBI登录号
- NM_014288, NP_055103
- UniProt
- Q13352
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