Serotonin Receptor 1B (HTR1B) Peptide
HTR1B
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all 5HT1B Receptor (HTR1B) products
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-HTR1B antibody (Catalog #: AVARP13042_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
- 别名
- 5-HT1B Peptide, 5-HT1DB Peptide, HTR1D2 Peptide, HTR1DB Peptide, S12 Peptide, 5-HT1Db Peptide, 5-HT1-LIKE Peptide, HTR1B Peptide, 5-HT-dro2B Peptide, 5-HT1BDro Peptide, 5-HT[1B]Dro Peptide, 5-HT[[1BDro]] Peptide, 5-HT[[1B]] Peptide, 5-HT[[1B]]DRO Peptide, 5-HT[[1B]]Dro Peptide, 5-HT[[dro2B]] Peptide, 5HT-R2B Peptide, 5HT-dro2B Peptide, 5HT-dro[[2B]] Peptide, 5HT1B Peptide, 5htdro2b Peptide, CG15113 Peptide, CG30126 Peptide, DRO2B Peptide, Dm5HTdro2B Peptide, Dmel\\CG15113 Peptide, Dmel_CG30126 Peptide, d5-HT1B Peptide, 5-HT-1B Peptide, zgc:194666 Peptide, zgc:194690 Peptide, 5-hydroxytryptamine receptor 1B Peptide, 5-hydroxytryptamine (serotonin) receptor 1B Peptide, HTR1B Peptide, Htr1b Peptide, 5-HT1B Peptide, htr1b Peptide
- 背景
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The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Alias Symbols: S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Protein Interaction Partner: HTR1A,HTR1B,HTR1D,HTR1A,HTR1B,HTR1D,GSTK1,HTR1D,NME2
Protein Size: 390 - 分子量
- 44 kDa
- 基因ID
- 3351
- NCBI登录号
- NM_000863, NP_000854
- UniProt
- P28222
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