Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) (N-Term) Peptide
HLA-DMA
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all HLA-DMA products
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- 蛋白结构域
- N-Term
- 宿主
- 人
- 资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-HLA-DMA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- 别名
- RT1.Ma Peptide, RT1.DMa Peptide, HLA-DMA Peptide, H-2Ma Peptide, H2-Ma Peptide, D6S222E Peptide, DMA Peptide, HLADM Peptide, RING6 Peptide, RT1 class II, locus DMa Peptide, SLA-DM alpha chain Peptide, major histocompatibility complex, class II, DM alpha Peptide, histocompatibility 2, class II, locus DMa Peptide, RT1-DMa Peptide, SLA-DMA Peptide, DLA-DMA Peptide, H2-DMa Peptide, HLA-DMA Peptide
- 背景
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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: CD74,CD82,HLA-DMB,HLA-DOA,HLA-DRA,HLA-DRB1,HLA-DRB1
Protein Size: 261 - 分子量
- 29 kDa
- 基因ID
- 3108
- NCBI登录号
- NM_006120, NP_006111
- UniProt
- Q31604
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