Glutaredoxin 2 (GRX2) (Middle Region) Peptide
GRX2
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all Glutaredoxin 2 (GRX2) products
- Glutaredoxin 2 (GRX2)
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL H
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-GLRX2 Antibody(ARP57792_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- Glutaredoxin 2 (GRX2)
- 别名
- ECK1049 Peptide, JW1051 Peptide, CGI-133 Peptide, GRX2 Peptide, 1700010P22Rik Peptide, AI645710 Peptide, Grx2 Peptide, glutaredoxin 2 (Grx2) Peptide, glutaredoxin Grx2 Peptide, thioredoxin Peptide, glutaredoxin 2 Peptide, glutaredoxin 2 (thioltransferase) Peptide, grxB Peptide, grx2 Peptide, AF_RS10790 Peptide, GLRX2 Peptide, Glrx2 Peptide
- 背景
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GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression of GLRX2 decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Alias Symbols: GRX2, bA101E13.1, CGI-133
Protein Interaction Partner: TXNRD1,TXNRD1
Protein Size: 164 - 分子量
- 18 kDa
- 基因ID
- 51022
- NCBI登录号
- NM_197962, NP_932066
- UniProt
- Q9NS18
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