This is a synthetic peptide designed for use in combination with anti-GATAD2B antibody (Catalog #: ARP39429_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta). Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.
Alias Symbols: P66beta, RP11-216N14.6
Protein Interaction Partner: KAT2B,MBD2,MBD3,SMAD2,FOXP1,FOXP2,Foxp2,HDAC1,HDAC2,MBD2,MBD3,MTA2,RBBP4,RBBP7