Family with Sequence Similarity 175, Member A (FAM175A) (C-Term) Peptide
FAM175A
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all CCDC98 (FAM175A) products
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
- 蛋白结构域
- C-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- DDRWQFKRSR LLDTQDKRSK ADTGSSNQDK ASKMSSPETD EEIEKMKGFG
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-FAM175A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
- 别名
- CCDC98 Peptide, abra1 Peptide, ccdc98 Peptide, fam175a Peptide, ABRA1 Peptide, 3830405G04Rik Peptide, 5630400M01Rik Peptide, AI506069 Peptide, AL024423 Peptide, AV118690 Peptide, Ccdc98 Peptide, RGD1305287 Peptide, zgc:103522 Peptide, abraxas 1, BRCA1 A complex subunit Peptide, Coiled-coil domain-containing protein 98 Peptide, BRCA1 A complex subunit Peptide, family with sequence similarity 175 member A Peptide, abraxas 2a, BRISC complex subunit Peptide, abraxas 1, BRCA1 A complex subunit S homeolog Peptide, ABRAXAS1 Peptide, abraxas1 Peptide, Abraxas1 Peptide, FAM175A Peptide, abraxas2a Peptide, abraxas1.S Peptide
- 背景
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FAM175A is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Alias Symbols: ABRA1, CCDC98, FLJ11520, FLJ12642, FLJ13614
Protein Interaction Partner: BRCA1,UIMC1,BABAM1,BARD1,BRCA1,BRCC3,BRE,HSPA4,UBC,UIMC1
Protein Size: 409 - 分子量
- 47 kDa
- 基因ID
- 84142
- NCBI登录号
- NM_139076, NP_620775
- UniProt
- Q6UWZ7
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