Class II, Major Histocompatibility Complex, Transactivator (CIITA) (Middle Region) Peptide
CIITA
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all CIITA products
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-CIITA antibody (Catalog #: ARP37976_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
- 别名
- CIITA Peptide, C2ta Peptide, EG669998 Peptide, Gm9475 Peptide, C2TA Peptide, CIITAIV Peptide, MHC2TA Peptide, NLRA Peptide, Mhc2ta Peptide, class II, major histocompatibility complex, transactivator Peptide, class II major histocompatibility complex transactivator Peptide, MHC class II transactivator Peptide, class II transactivator Peptide, CIITA Peptide, LOC710761 Peptide, ciita Peptide, LOC100443575 Peptide, Ciita Peptide, LOC100736732 Peptide
- 背景
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CIITA is a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: C2TA, CIITA IV, MHC2TA, NLRA, CIITAIV
Protein Interaction Partner: ACTB,HIST4H4,POLR2A,HDAC4,HDAC5,KAT2B,NCOA1,NFYB,PRKACA,RFX5,RFXANK,TAF6,XPO1,ZXDC,CDK1,MAPK1,MAPK3,NCOA1,RFX5,RFXANK,XPO1
Protein Size: 1130 - 分子量
- 123 kDa
- 基因ID
- 4261
- NCBI登录号
- NM_000246, NP_000237
- UniProt
- P33076
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