CD22 Molecule (CD22) (C-Term) Peptide
CD22
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all CD22 products
- CD22 (CD22 Molecule (CD22))
- 蛋白结构域
- C-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- YSALHKRQVG DYENVIPDFP EDEGIHYSEL IQFGVGERPQ AQENVDYVIL
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-CD22 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- CD22 (CD22 Molecule (CD22))
- 别名
- A530093D23 Peptide, Lyb-8 Peptide, Lyb8 Peptide, SIGLEC-2 Peptide, SIGLEC2 Peptide, siglec-2 Peptide, CD22 antigen Peptide, CD22 molecule Peptide, Cd22 Peptide, CD22 Peptide
- 背景
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CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: AP2M1,ATP2B4,CD19,GRB2,HP,IGHM,INPP5D,LCP2,LYN,PIK3R1,PLCG1,PTPN6,PTPRC,SHC1,ST6GAL1,SYK,AP2A1,AP2M1,CD19,GRB2,INPP5D,LYN,PLCG1,PTPN6,PTPRC,SHC1,SYK
Protein Size: 847 - 分子量
- 95 kDa
- 基因ID
- 933
- NCBI登录号
- NM_001771, NP_001762
- UniProt
- P20273
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