beta-Transducin Repeat Containing (BTRC) (C-Term) Peptide
BTRC
适用: 小鼠
宿主: 合成
BP, WB
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- 抗原 See all BTRC products
- BTRC (beta-Transducin Repeat Containing (BTRC))
- 蛋白结构域
- C-Term
- 宿主
- 小鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Btrc Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- BTRC (beta-Transducin Repeat Containing (BTRC))
- 别名
- BTRC Peptide, Beta-TrCP Peptide, betaTrCP Peptide, btrcp Peptide, btrcp1 Peptide, fbw1a Peptide, fbxw1 Peptide, fbxw1a Peptide, fwd1 Peptide, btrc Peptide, beta-TrCP Peptide, BETA-TRCP Peptide, FBW1A Peptide, FBXW1 Peptide, FBXW1A Peptide, FWD1 Peptide, bTrCP Peptide, bTrCP1 Peptide, beta-TrCP1 Peptide, btrc-a Peptide, Beta-Trcp1 Peptide, Fbw1a Peptide, HOS Peptide, Slimb Peptide, b-TrCP Peptide, mKIAA4123 Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase Peptide, beta-transducin repeat containing Peptide, beta-TrCP Peptide, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog Peptide, beta-transducin repeat containing protein Peptide, BTRC Peptide, btrc Peptide, LOC100634006 Peptide, Btrc Peptide, btrc.S Peptide
- 背景
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Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Size: 605 - 分子量
- 69 kDa
- 基因ID
- 12234
- NCBI登录号
- NM_001037758, NP_001032847
- UniProt
- Q3ULA2
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