Breast Cancer 1 (BRCA1) Peptide
BRCA1
适用: 人
宿主: 合成
BP, WB, IHC
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- 抗原 See all BRCA1 products
- BRCA1 (Breast Cancer 1 (BRCA1))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-BRCA1 antibody (Catalog #: AVARP02017_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- BRCA1 (Breast Cancer 1 (BRCA1))
- 别名
- BRCAI Peptide, BRCC1 Peptide, BROVCA1 Peptide, IRIS Peptide, PNCA4 Peptide, PPP1R53 Peptide, PSCP Peptide, RNF53 Peptide, iris Peptide, pscp Peptide, brcai Peptide, brcc1 Peptide, rnf53 Peptide, brca1 Peptide, BRCA1 Peptide, LOC100224649 Peptide, BRCA1, DNA repair associated Peptide, breast cancer 1 Peptide, breast cancer 1, early onset Peptide, breast cancer 1 L homeolog Peptide, BRCA1 Peptide, brca1 Peptide, LOC755086 Peptide, Brca1 Peptide, brca1.L Peptide
- 背景
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BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45 % of inherited breast cancer and more than 80 % of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.
Alias Symbols: IRIS, PSCP, BRCAI, BRCC1, PNCA4, RNF53, BROVCA1, PPP1R53
Protein Interaction Partner: ETS2,CREBBP,EP300,MAP3K3,MED1,BRCA1,SMAD2,SMAD3,SMAD4,UBB,ACACA,ATR,BRCA2,CCNA1,CCNB1,CCND1,CDK2,CDK4,CSNK2B,E2F1,E2F4,FANCA,HDAC1,HDAC2,JUN,JUNB,JUND,LMO4,MSH2,MSH6,MYC,NFYA,NMI,NUFIP1,POU2F1,RAD51,RAD51,RB1,RBBP4,RBBP7,RBBP8,SP1,TP53,TP53,ABL1,ACACA,AKT1,AR,ATF1,ATR,AURKA,BAP1,BARD1,BRAP,BRCA1,BRCA2,BRCC3,BRIP1,CASP3,CCNA1,CCNA2,CCNB1,CCND1,CDK1,CDK2,CDK4,CDK7,CHEK2,CLSPN,COBRA1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CTBP1,DCLRE1C,DHX9,E2F1,E2F4,ELK1,EP300,ESR1,FAM175A,FANCA,FANCD2,FHL2,GFI1B,H2AFX,HDAC1,HDAC2,IFI16,JAK1,JAK2,JUN,JUNB,JUND,KPNA2,KPNA6,LMO4,MAP3K3,MDC1,MED1,MED21,MLH1,MNAT1,MYC,NBN,NFKB1,NFYA,NMI,NUFIP1,POLR2A,POLR2K,POU2F1,PPP1CA,PSAP,RAD51,RB1,RBBP4,RBBP7,RBBP8,RELA,RFC1,SMAD2,SMAD3,SMAD4,SMARCA2,SMARCA4,SMC1A,SP1,STAT1,STAT3,STAT5A,TOP2A,TP53,TP53BP1,TRRAP,TUBA4A,TUBB,TUBG1,UBB,UBE2D3,UBE2L3,USF2,VCP,XRCC1,YY1,ZNF350,ABL1,ACACA,AKT1,APLP2,AR,ASM4,ATF1,ATM,ATR,AURKA,BACH1,BARD1,BLM,BRAP,BRCA1,BRCA2,BRCC3,BRD7,BRE,BRIP1,CCNA1,CCNA2,CCNB1,CCND1,CCNE1,CCR4,CDK1,CDK16,CDK2,CDK4,CDK5,CDK8,CDS1,CHEK2,CLSPN,COBRA1,CREB1,CREBBP,CSNK2A1,CSNK2B,CSTF1,CSTF2,CTBP1,CTCFL,DEF1,DHH1,DHX9,DNAJA3,E2F4,ELK4,EP300,ESR1,ETS1,FANCA,FANCD2,FHL2,FLI1,GTF2E1,GTF2F1,GTF2H4,H2AFX,H2AFY,HDAC1,HDAC2,HIST2H2AC,HIST2H3C,HSPA8,Ifi204,JAK1,JAK2,JUN,JUNB,JUND,KIF1B,KPNA2,LMO4,MAP3K3,MAP4K4,MDC1,MED1,MED13,MED17,MED21,MED23,MED24,MLH1,MLP2,MRE11A,MRPL39,MSH2,MSH3,MSH6,MYC,NBN,NCOA2,NCOA3,NFYA,NMI,NPM1,NUFIP1,NUP120,NUP133,NUP153,NUP170,NUP188,NUP2,ORC2L,ORC3L,PEG3,POLR2A,POM34,POU2F1,PPP1CA,PPP1CB,PPP1R3A,PRKDC,RAD50,RAD51,RB1,RBBP4,RBBP7,RBBP8,RBL1,RBL2,RELA,RFC1,RPL31,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCC2,SMARCD2,SP1,SPT4,SPT5,STAT1,STAT5A,SUB1,TOP2A,TP53,TP53BP1,TUBG1,UBA1,UBC,UBE2D1,UBE2L3,UBE3A,UIMC1,USF2,VCP,WDR48,WNT2B,XIST,ZCCHC8,ZNF350
Protein Size: 680 - 分子量
- 76 kDa
- 基因ID
- 672
- NCBI登录号
- NM_007298, NP_009229
- UniProt
- P38398
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