AKT Interacting Protein (AKTIP) (Middle Region) Peptide
AKTIP
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all AKTIP products
- AKTIP (AKT Interacting Protein (AKTIP))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-AKTIP antibody (Catalog #: ARP56199_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- AKTIP (AKT Interacting Protein (AKTIP))
- 别名
- FT1 Peptide, FTS Peptide, cb798 Peptide, fts Peptide, zgc:77699 Peptide, fts-A Peptide, aktip Peptide, fts-B Peptide, MGC133931 Peptide, AL023020 Peptide, Fif Peptide, Ft Peptide, Ft1 Peptide, Fts Peptide, AKT interacting protein Peptide, akt interacting protein Peptide, AKT interacting protein L homeolog Peptide, AKT interacting protein S homeolog Peptide, thymoma viral proto-oncogene 1 interacting protein Peptide, AKTIP Peptide, aktip Peptide, aktip.L Peptide, aktip.S Peptide, Aktip Peptide
- 背景
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AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Alias Symbols: FT1, FTS
Protein Interaction Partner: AKT1,ASS1,C10orf2,CTBP2,EXOC7,GTF3C1,HOOK2,IMMT,KIAA1377,PDPK1,POLA2,RPA1,UTP14A,AKT1,ASS1,C10orf2,CTBP2,DCTN1,EXOC7,GTF3C1,HDLBP,HOOK1,HOOK2,IARS,IMMT,KIAA1377,PDS5A,POLA2,RPA1,TIMM50,UTP14A
Protein Size: 292 - 分子量
- 33 kDa
- 基因ID
- 64400
- NCBI登录号
- NM_001012398, NP_001012398
- UniProt
- Q9H8T0
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