This is a synthetic peptide designed for use in combination with anti-ADRB2 antibody (Catalog #: AVARP00006_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
This protein is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Protein Interaction Partner: EIF2B1,SLC9A3R1,SLC9A3R2,ADRB3,AKAP12,AKAP5,ARR3,ARRB1,CSK,EIF2B1,GNA11,GNA14,GNA15,GPRASP1,GRB2,GRK5,GRK6,HTR4,IL1B,INSR,KCNJ6,KCNJ9,NOS1,OPRD1,PRKCD,SLC9A3R1,SLC9A3R2,SRC,ADRB2,ADRBK1,AKAP12,Arrb2,EIF2B1,GRB2,GRK6,KCNJ3,KCNJ5,OPRD1,PPP3CA,SLC9A3R1,SLC9A3R2,SRC,UBC