A synthetic peptide for use as a blocking control in assays to test for specificity of KCNQ2 antibody, Alternative Names: KCNQ2 control peptide, KCNQ2 antibody Blocking Peptide, Anti-KCNQ2 Blocking Peptide, Potassium Voltage-Gated Channel Kqt-Like Subfamily Member 2 Blocking Peptide, KCNQ2, KCNQ-2, KCNQ 2, KCNQ-2 Blocking Peptide, KCNQ 2 Blocking Peptide
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).